Novel Applications of Immuno-bioinformatics in Vaccine and Bio-product Developments at Research Institutes

AUTHORS

M. M. Ranjbar 1 , * , M. M. Ebrahimi 2 , S. Shahsavandi 2 , T. Farhadi 3 , A. Mirjalili 4 , M. Tebianian 5 , M. H. Motedayen 5

1 Department of FMD, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

2 Department of Avian Vaccine,Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

3 Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Department of Genetics, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

5 Department of Serotherapy, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

How to Cite: Ranjbar M M, Ebrahimi M M, Shahsavandi S, Farhadi T, Mirjalili A, et al. Novel Applications of Immuno-bioinformatics in Vaccine and Bio-product Developments at Research Institutes, Arch Razi Inst. 2019 ; 74(3):e98498. doi: 10.22092/ari.2018.122523.1224.

ARTICLE INFORMATION

Archives of Razi Institute: 74 (3); 219-233
Published Online: October 01, 2019
Article Type: Review
Received: August 07, 2018
Accepted: November 04, 2018
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Abstract

There are many challenges in the field of public health sciences. Rational decisions are required in order to treat different diseases, gain knowledge and wealth regarding research, and produce biological or synthetic products. Various advances in the basic laboratory science, computer science, and the engineering of biological production processes can help solve the occurring problems. Bioinformatics is defined as a field of science combined of biology, mathematics, physics, chemistry, and computer sciences. Recently, bioinformatics has been extensively used in the designing of the epitope, vaccines, antibodies, adjuvants, diagnostic kits, and therapeutic purposes (e.g., proteins, peptides, or small molecules). Moreover, bioinformatics includes chemoinformatics that has been employed to produce various biological or chemical products to target and combat pathogens. Bioinformatics is involved in other areas of data analysis and prediction, such as structural biology, system biology, phylogeny, population genetics, and next-generation data sequencing. To the best of our knowledge, no published study coherently described the benefits of bioinformatics fields applied for medication development or diagnostic aims in bio-productive and pharmaceutical/vaccine companies. Therefore, in the current review, we attempted to present the available bioinformatics resources, practical experiences, and other findings in the mentioned field along with providing a harmonized and applied model(s). The key points presented in the current review may help to elevate production and reduce the costs for the development of novel vaccines, medicines, and antibodies. In addition, these methods can facilitate the identification of organisms and may guarantee the quality of biological products.

Keywords

Bioinformatics Biological products Immunoinformatics Vaccine

© 2019, Archives of Razi Institute. Razi Vaccine and Serum Research Institute.

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